Association between Oxidative Stress Biomarkers and Glutathione Transferases Polymorphisms as an Indicator Susceptibility for Benzene's Effect on Workers at A Gasoline Filling Station in Baghdad

Abstract

Oxidative stress is considered one of the most important processes that result in significant damage and adverse effects on human and animal health alike. Regular exposure to gasoline by employees of private fuel stations poses many occupational and environmental risks. The purpose of this work and this study is to compare and evaluate the health of employees at a Baghdad fuel station affiliated with the Iraqi Ministry of Oil. This study focused on how occupational exposure to gasoline affects oxidative stress indicators (MDA, GSH, CAT, and POD). The study aimed to identify any potential links between gasoline metabolism and GST gene polymorphisms. The mean oxidative stress values ​​for MDA, GSH, CAT, and POD differed significantly between the employees and the control group (P < 0.01). According to genetic analysis, the fuel station employees and the control group differed significantly in their GSTM1 and GSTT1 variations. This study yielded the following allele frequencies for GSTM1-null genotypes in the worker population: 36.5%, GSTT1-null (19.42%), and CSTP1-null (7.7%), respectively. Associations were also found between GSTM1-null and several benzene exposure-related changes.